Paternal Age as a Risk Factor

[Paternal age as a risk factor for congenital malformations].

BACKGROUND The role of advanced maternal age as a risk factor for congenital malformations in offspring is known. However, the influence of paternal age is not clear. AIM To evaluate the association between advanced paternal age and the risk for congenital malformations. PATIENTS AND METHODS Analysis of maternal and paternal age of cases (malformed newborns) and controls from ECLAMC Databas...

AGE proteins as a causative factor in Alzheimer's Disease

The reaction between reducing sugars and protein free amines, known as the Maillar reaction results in the formation of advanced glycation endproducts (AGEs). AGE modification changes the structure of proteins to amyloid cross-beta structure. These protein structures can activate receptors known as RAGE on glial cells (microglia and astrocytes), and induce the expression of inducible nitric oxi...

AGE proteins as a causative factor in Alzheimer's Disease

The reaction between reducing sugars and protein free amines, known as the Maillar reaction results in the formation of advanced glycation endproducts (AGEs). AGE modification changes the structure of proteins to amyloid cross-beta structure. These protein structures can activate receptors known as RAGE on glial cells (microglia and astrocytes), and induce the expression of inducible nitric oxi...

Advancing Paternal Age and Risk of Autism

Metabolic Syndrome as a Risk Factor for Osteoarthritis

  Metabolic syndrome refers to a set of conditions that include high blood pressure, increased insulin level in the blood, the accumulation of the excess fat around the abdomen, and increased blood lipids. In metabolic syndrome, the vast majority of these conditions are simultaneously present, and the risk of developing heart disease, stroke, and diabetes rises. Besides, osteoarthritis or degen...